Renal Toxicity and Haematological Effect of Luter (An Antimalarial Drug) in Albino Rats

Background and Objective: Malaria is a common disease in tropical and developing countries that affects humans and other animals. Several antimalarial drugs have been reported to cause various side effects on various body organs. This study investigated the effect of luter, an antimalarial drug, on some renal function and haematological parameters in albino rats. Materials and Methods: Sixteen adult male albino rats were dived into four groups of four rats each. Group A was the normal control, while groups B, C and D were administered 8.0, 16.0 and 24.0 mg kg^–1 b.wt., of luter solution, respectively, through oral intubation for 7 days. After 7 days, blood samples were collected from the rats for the assessment of the concentrations of creatinine, urea and uric acid, including Haemoglobin (Hb), Packed Cell Volume (PCV), White Blood Cell (WBC), Red Blood Cell (WBC) and Platelets (PLT) counts. Results: A decrease in feed and water intake accompanied by a decrease in physical activities and body weights was observed in the test animals compared to the control. Also, the result of blood assessments showed significantly (p<0.05) increases in the levels of creatinine, urea, uric acid and platelets, with significant (p<0.05) decreases in haemoglobin, packed cell volume, white blood cells and red blood cells’ levels in the test groups compared to the control in a dose-dependent manner. Conclusion: Findings suggest that the antimalarial drug, luter may possess both renal and haematological adverse effects. Hence, luter may not be suitable for patients already having renal and haematological disorders.