GC-MS and Antioxidative Effects of Poly Herbal Formulation of Persea americana Seed Against Ethanol-Induced Gastric Ulcer in Rats

Background and Objective: Plant-derived natural products have considerable significant attention due to their various pharmacological properties and functions. Avocado (Persea americana Mill.), is a fruit that is native to Central America. GC-MS analyses of avocado samples showed α-tocopherol, squalene, cycloartenol acetate, β-sitosterol, campesterol and stigmasterol. This study aims to check the gastroprotective and antioxidant effect of avocado seed extract on gastric ulcer. Materials and Methods: A total of 60 experimental rats were used and divided into a group of six in two experimental designs and administered treatments with the crude extract of virgin avocado. Results: Results were expressed as Mean±Standard Error of the Mean (SEM). Statistical significance was determined using a One-way Analysis of Variance (ANOVA) followed by Tukey’s post hoc Test. Values of p<0.05 were considered to be significant. The result of the GC-MS profile of the ethanol crude extract of avocado seed extract was found to compose of 30 chemical constituents which can be used to manage different kinds of ailments. Conclusion: Avocado seed extract has potential antioxidant activity in vitro and in vivo. Oral administration of Avocado seed extract once daily for 7 days alleviates gastric ulcers induced by ethanol, but more significant was observed with the formulation.