Cocos nucifera Water Ameliorated Hepatic Complications and Attenuated Oxidative Stress in Cadmium-Induced Hepatotoxicity

Background and Objectives: Cadmium (Cd) is a heavy metal widely distributed in the environment due to industrial, agricultural and natural sources. Chronic exposure to cadmium is known to induce hepatotoxicity, leading to severe liver damage and dysfunction. Hence, the effect of Cocos nucifera water on indices of liver function and oxidative stress in cadmium-induced hepatotoxicity was investigated in albino rats. Materials and Methods: The study involved 30 Wistar rats divided into 6 groups, with control groups receiving normal saline. Hepatotoxicity was induced in groups B, D, E and F by oral cadmium administration. Group B remained untreated, while groups D through F were treated with varying doses of Cocos nuciferawater. The proximate, vitamin and mineral contents of Cocos nuciferawater were determined. Results: The cadmium administration to rats increased hepatic enzyme activities, decreased catalase and reduced glutathione levels. However, treatment with Cocos nucifera water significantly decreased these effects and restored liver architecture to normal. The study confirmed that cadmium can be a potential health risk for humans. Conclusion: The Cocos nucifera water maybe beneficial in treating liver complications.