Research Article | Open Access

Effects of Synergistic Consumption of Aqueous Extract of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera on Hematological Indices in Male Rat Model

    Barizoge Cletus Lemii

    Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, Rivers State University, Nigeria

    Tamuno-Boma Odinga

    Department of Biochemistry, Faculty of Science, Rivers State University, Nigeria

    Iyaeneomi Ransome Daka

    Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, Rivers State University, Nigeria

    Christine Umanu Gabriel-Brisibe

    Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medical Sciences, Rivers State University, Nigeria

    Sarah Kelechi Enebeli

    Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, Rivers State University, Nigeria

    Iyingiala Austin-Asomeji

    Department of Community Medicine, Faculty of Clinical Sciences, College of Medical Sciences, Rivers State University, Nigeria

    Ucheawaji Felicia Edward

    Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, Rivers State University, Nigeria


Received
17 Nov, 2023
Accepted
13 Feb, 2024
Published
31 Mar, 2024

Background and Objective: The 80% of the population worldwide depend heavily on the use of herbs and supplements singly or as combinations for therapeutic purposes (ameliorative or prophylactically), enhancement or as supplements. This study assessed the effects of a synergistic mixture of Cyperus escunlentus, Phoenix dactylifera and Cocos nucifera (STDC) on selected hematological indices in a male rat model. Materials and Methods: Acute toxicity LD50 of STDC was done and thereafter 15 healthy male Wistar rats weighing between 230-250 g procured from the Pharmacology and Therapeutics Department of the Rivers State University Port Harcourt were allotted into 3 groups containing 5 rats in each group: Control, STDC200 mg/kg and STDC 400 mg/kg groups. The test rats were administered doses of STDC with feed and water as required for 21 days after which blood samples were taken for hematological analysis using standard laboratory procedures. Descriptive statistics were computed and expressed as Mean±SD. One-way Analysis of Variance (ANOVA) and Tukey’s test were performed. The p<0.05 was considered statistically significant. Results: The acute toxicity LD50 as >2404.2 mg/kg while WBC and differential counts (neutrophils, lymphocytes, basophils and eosinophils) were non-significantly (p<0.05) elevated, except monocyte having a non-significantly (p<0.05) reduced value. The RBC, PCV and Hb also manifested a statistically non-significant (p<0.05) increased plasma concentrations  as  well  as  a non-significant (p<0.05) decrease in platelet count. Conclusion: Thus, STDC could be useful in improving immunity as well as reticulocyte synthesis and functions.

How to Cite this paper?


APA-7 Style
Lemii, B.C., Odinga, T., Daka, I.R., Gabriel-Brisibe, C.U., Enebeli, S.K., Austin-Asomeji, I., Edward, U.F. (2024). Effects of Synergistic Consumption of Aqueous Extract of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera on Hematological Indices in Male Rat Model. Asian Journal of Biological Sciences, 17(1), 156-168. https://doi.org/10.3923/ajbs.2024.156.168

ACS Style
Lemii, B.C.; Odinga, T.; Daka, I.R.; Gabriel-Brisibe, C.U.; Enebeli, S.K.; Austin-Asomeji, I.; Edward, U.F. Effects of Synergistic Consumption of Aqueous Extract of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera on Hematological Indices in Male Rat Model. Asian J. Biol. Sci 2024, 17, 156-168. https://doi.org/10.3923/ajbs.2024.156.168

AMA Style
Lemii BC, Odinga T, Daka IR, Gabriel-Brisibe CU, Enebeli SK, Austin-Asomeji I, Edward UF. Effects of Synergistic Consumption of Aqueous Extract of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera on Hematological Indices in Male Rat Model. Asian Journal of Biological Sciences. 2024; 17(1): 156-168. https://doi.org/10.3923/ajbs.2024.156.168

Chicago/Turabian Style
Lemii, Barizoge, Cletus, Tamuno-Boma Odinga, Iyaeneomi Ransome Daka, Christine Umanu Gabriel-Brisibe, Sarah Kelechi Enebeli, Iyingiala Austin-Asomeji, and Ucheawaji Felicia Edward. 2024. "Effects of Synergistic Consumption of Aqueous Extract of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera on Hematological Indices in Male Rat Model" Asian Journal of Biological Sciences 17, no. 1: 156-168. https://doi.org/10.3923/ajbs.2024.156.168